Publications by authors named "T Candler"
Article Synopsis
- Achondroplasia is a genetic condition that leads to significant short stature and various medical challenges, and infigratinib is a new treatment being tested for children affected by this disorder.
- A phase 2 study involved 72 children aged 3 to 11, testing varying doses of infigratinib over 6 months, with adjustments possible during a further 12-month period, focusing on the safety and height growth of the participants.
- Results indicated that all participants experienced mild to moderate side effects, but none stopped treatment; most significantly, children in the highest dose group showed a notable increase in height growth compared to baseline, suggesting the treatment could be effective.
Article Synopsis
- A 1-month-old baby was very sick with a fever and needed help because his body was losing too much water.
- Doctors found that his blood had too much salt and other problems, suggesting he might have a type of diabetes insipidus.
- After tests, they discovered a genetic issue making it hard for his body to use a hormone called AVP, leading to a diagnosis of AVP resistance, not a lack of it.
Objective: With one in five children in England living with obesity, we mapped the geographical distribution and format of child weight management services provided by acute National Health Service (NHS) trusts across England, to identify breadth of service provision.
Design: A cross-sectional survey.
Setting: The survey was sent to acute NHS trusts (n=148) in England in 2020, via a freedom of information request.
Objective: To establish short-term and medium-term complications 1-year postdiagnosis, of acute pancreatitis (AP) in children aged 0-14 years.
Design: One-year follow-up of a prospective monthly surveillance of new cases of AP in children under 15 years through the British Paediatric Surveillance Unit (BPSU) from April 2013 to April 2014.
Setting: A monthly surveillance of >3700 consultant paediatricians and paediatric surgeons in the UK and Ireland using the BPSU.
PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, and gene methylation is reported to be sensitive to the periconceptional environment. Using a novel recall-by-epigenotype study in Gambian children, we found that hypomethylation at age 2 years is associated with a 21% increase in thyroid volume and an increase in free thyroxine (T4) at 5 to 8 years, the latter equivalent to 8.4% of the normal range.
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