Publications by authors named "T Cadoudal"
Scope: Vitamin A and its metabolites, such as retinoic acids (RA), are related to metabolic diseases, in particular insulin resistance and obesity. Here, we studied the roles of 9-cis RA and all-trans RA on the regulation of pyruvate dehydrogenase kinase 4 (PDK4), an enzyme involved in fatty acid reesterification, which is a crucial metabolic pathway in adipose tissue (AT) lipid homeostasis.
Methods And Results: 9-cis RA and all-trans RA treatment of human and murine AT explants, as well as adipocytes (3T3-F442A cell line) induces PDK4 expression both at the mRNA and the protein level, via a transcriptional mechanism.
Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells.
View Article and Find Full Text PDFArticle Synopsis
- - LEOPARD syndrome, also known as Noonan syndrome with multiple lentigines, is a rare genetic disorder characterized by various developmental issues including heart defects, distinct physical features, short stature, and growth retardation, primarily due to PTPN11 gene mutations.
- - In a study using a mouse model with a common LS mutation, researchers found that these mice had significantly less body fat and were resistant to obesity, suggesting that the mutation impacts fat storage and energy expenditure.
- - Preliminary findings from human patients indicate that many affected individuals also have lower body mass index (BMI) and reduced fat, revealing potential metabolic benefits from the disorder while possibly complicating certain aspects of health related to LS.
Purpose: Resveratrol inhibits lipid accumulation but suffers from limited bioavailability. The anti-depressive agent phenelzine limits adipogenesis in various models of cultured preadipocytes, and this hydrazine derivative also inhibits de novo lipogenesis in mature adipocytes. It was therefore tested whether resveratrol effects on adiposity reduction and glucose tolerance improvement could be reinforced by co-administration with phenelzine.
View Article and Find Full Text PDFImpairment of adipose tissue in Prader-Willi syndrome rescued by growth hormone treatment.
Int J Obes (Lond)
September 2014
Background: Prader-Willi syndrome (PWS) results from abnormalities in the genomic imprinting process leading to hypothalamic dysfunction with an alteration of growth hormone (GH) secretion. PWS is associated with early morbid obesity and short stature which can be efficiently improved with GH treatment.
Objectives: Our aims were to highlight adipose tissue structural and functional impairments in children with PWS and to study the modifications of those parameters on GH treatment.