Publications by authors named "T C Tuominen"
Objectives: Elevations of cardiac troponin T (cTnT) levels are common after strenuous exercise. We assessed whether the composition of cTnT release after marathon race differs from that of acute myocardial infarction (MI).
Methods: Troponin composition was analysed in plasma samples taken from 45 runners after marathon race and from 84 patients with type 1 MI.
Novel troponin fragmentation assay to discriminate between Takotsubo syndrome and acute myocardial infarction.
Eur Heart J Acute Cardiovasc Care
December 2024
Article Synopsis
- Cardiac troponin levels, elevated in Takotsubo syndrome (TTS), show significant overlap with acute myocardial infarction (MI), prompting a study on their fragmentation.
- The study measured long forms of cardiac troponin T (cTnT) in TTS (24 patients) versus Type 1 MI (84 patients), finding a notably lower troponin ratio in TTS, which indicates different cTnT fragmentation patterns.
- Results suggest that the troponin ratio is more effective than total cTnT in differentiating between TTS and MI, highlighting its potential as a diagnostic tool for elevated cTnT levels.
Article Synopsis
- A novel, highly sensitive immunoassay for long cardiac troponin T (cTnT) was developed using upconverting nanoparticles to improve detection for acute myocardial infarction (AMI).
- The new assay achieved significantly lower detection (0.40 ng/L) and quantitation (1.79 ng/L) limits compared to previous methods and was effective in distinguishing between patients with non-ST elevation myocardial infarction and end-stage renal disease.
- The findings suggest that this novel assay could enhance the use of long cTnT as a specific biomarker for AMI, with promising clinical implications.
The European Union's responses to the COVID-19 crisis: How to fight a pandemic with the internal market.
Maastrich J Eur Comp Law
August 2022
In a liberalized market economy, states tend to purchase supplies required for producing publicly funded services, such as healthcare, from the markets instead of producing them themselves. The availability of critical supplies thus becomes a question of supply-side availability and supply chain management, and therefore their availability is conceptualized in terms of security of supply. The European Union's security of supply policy has focused on energy and security and defence.
View Article and Find Full Text PDFWe investigated the short- and long-term effects of two different evidence-based mindfulness training on students' stress and well-being. A randomised controlled trial with three measurement points (baseline, post-intervention, and 4 months post-intervention) was conducted among undergraduate students of medicine, dentistry, psychology, and logopaedics at the University of Helsinki. The participants were randomly assigned into three groups: (1) face-to-face mindfulness training based on the Mindfulness Skills for Students course (n = 40), (2) a web-based Student Compass program using Mindfulness and Acceptance and Commitment therapy (n = 22), and (3) a control group that received mental health support as usual (n = 40).
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