Publications by authors named "T C Sluckin"
Article Synopsis
- Inadequate treatment of enlarged lateral lymph nodes (LLNs) in rectal cancer patients leads to higher local recurrence rates, but LLN dissection (LLND) may help reduce this risk.
- This study will evaluate the outcomes of a standardized treatment approach after multidisciplinary training, aiming for a 50% reduction in local recurrence rates among patients with rectal cancer and enlarged LLNs.
- The trial involves 200 patients and will assess important outcomes such as local recurrence rates, morbidity, disease-free survival, and quality of life over three years post-surgery, with ethical approval from a Dutch medical ethics board.
Aim: Literature on nationwide long-term permanent stoma rates after rectal cancer resection in the minimally invasive era is scarce. The aim of this population-based study was to provide more insight into the permanent stoma rate with interhospital variability (IHV) depending on surgical technique, with pelvic sepsis, unplanned reinterventions and readmissions as secondary outcomes.
Method: Patients who underwent open or minimally invasive resection of rectal cancer (lower border below the sigmoid take-off) in 67 Dutch centres in 2016 were included in this cross-sectional cohort study.
Aim: This study aimed to determine the consequences of the new definition of rectal cancer for decision-making in multidisciplinary team meetings (MDT). The new definition of rectal cancer, the lower border of the tumour is located below the sigmoid take-off (STO), was implemented in the Dutch guideline in 2019 after an international Delphi consensus meeting to reduce interhospital variations.
Method: All patients with rectal cancer according to the local MDT, who underwent resection in 2016 in the Netherlands were eligible for this nationwide collaborative cross-sectional study.
Background: Detection of grade 3-4 extra mural venous invasion (mrEMVI) on magnetic resonance imaging (MRI) is associated with an increased distant metastases (DM)-rate. This study aimed to determine the impact of different grades of mrEMVI and their disappearance after neoadjuvant therapy.
Methods: A Dutch national retrospective cross-sectional study was conducted, including patients who underwent resection for rectal cancer in 2016 from 60/69 hospitals performing rectal surgery.
Article Synopsis
- In the Netherlands, the use of neoadjuvant radiotherapy for rectal cancer decreased significantly from 2011 to 2016 following a guideline revision, raising concerns about the treatment of locally recurrent rectal cancer (LRRC).
- A study compared two national cohorts from 2011 and 2016, analyzing outcomes such as time to LRRC, metastasis presence, treatment intent, and survival rates.
- Despite the decline in neoadjuvant treatment, the rates of LRRC remained similar, but patients in 2016 had a greater chance of receiving curative treatments and showed improved two-year survival rates after developing LRRC.