Publications by authors named "T C Richard"
Resveratrol and its glucoside, piceid, are the primary stilbenes present in wine. These compounds are well known for their pharmaceutical properties. However, these compounds can undergo chemical transformations in wines, such as polymerization in the presence of metallic reagents.
View Article and Find Full Text PDFBackground: The dermal extracellular matrix (ECM) is a dynamic scaffold composed mainly of proteins, with collagen as the key structural component providing resilience and support to the skin. Post-menopause, declining estrogen levels lead to a significant reduction in skin health, notably a 30% decrease in collagen types I and III within 5 years.
Aim: To discover natural extracts that stimulate collagen production.
The extraction of polyphenols from myrtle (Myrtus communis L.) fruits using a conventional solid-liquid extraction was optimized using a single-factor experiment approach. The influence of several parameters such as type of solvent (50% acetone, 50% methanol, 50% ethanol, and water), solvent concentration (30-100%; v/v), solvent acidity (0-0,1 N), temperature (20°C-40°C) and time (30-360 min) on the yield extraction of total phenolic content (TPC), total flavonoid content (TFC), total proanthocyanidin content (TPAC), and on the antioxidant activity: DPPH-radical scavenging activity (DPPH-RSA), ABTS-radical scavenging activity (ABTS-RSA) and ferric reducing power (FRP) was studied.
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- The study explored the effectiveness of five different HILIC stationary phases for retaining various polyphenols, discovering that silica-based supports generally did not perform well except for anthocyanins.
- Retention of phenolics was most effective with zwitterionic, amide, and amino stationary phases, and the choice of mobile phase, particularly using formic acid instead of TFA, significantly influenced retention results.
- The research highlighted the advantages of using mass spectrometry as a detector for quantifying polyphenols in complex natural extracts, particularly under conditions where resolution between compounds was difficult.
Article Synopsis
- Bacterial pneumonia can cause serious breathing problems, and sometimes patients need a special treatment called veno-venous extracorporeal membrane oxygenation (ECMO) when regular ventilation doesn't work.
- A case study was about a 39-year-old woman with severe pneumonia and other health issues who needed 30 days of ECMO and over 50 days on a breathing machine, facing many complications.
- The doctors believe that even badly damaged lungs can heal if given enough time and the right care, which might change how doctors decide to use ECMO in the future.