This scoping review evaluated the efficacy/effectiveness and utilization of complementary and integrative health (CIH) therapies for pain management within the Military Health System (MHS). Specifically, it aimed to assess evidence-based modalities such as acupuncture, biofeedback, hypnosis, massage therapy, meditation, guided imagery, Tai Chi/Qi Gong, and yoga, which are part of the Veterans Administration's (VA) Whole Health program. The goal was to determine their effectiveness in military service members and understand their utilization in the MHS, as well as explore CIH research in the MHS to identify gaps.
View Article and Find Full Text PDFPurpose: EGFR-targeting monoclonal antibodies are essential for managing RAS WT metastatic colorectal cancer (mCRC), but their limited efficacy necessitates exploring immunological and metabolic factors influencing response. This study evaluated glutamine metabolism targeting with EGFR inhibition to identify response biomarkers in patients with prior anti-EGFR treatment progression.
Experimental Design: We conducted a phase I/II trial in KRAS WT mCRC patients, combining panitumumab and CB-839, hypothesizing that dual inhibition of glutamine metabolism and MAPK signaling would enhance outcomes.
A 38-year-old male patient sustained a concussion in May 2017 while playing hockey. Despite initially following standard treatments and rest, he continued to experience post-concussive symptoms. Approximately two weeks later, he sought alternative therapy at The Oxford Center in Brighton, Michigan, where he was introduced to hyperbaric oxygen therapy (HBOT).
View Article and Find Full Text PDFBackground Context: Since the early 2000s, various expandable spinal fusion cages have been developed to facilitate less invasive procedures, however, expandable cages have often been evaluated as a homogeneous group, neglecting differences in shape, size, material, expandability and lordotic adjustability. This systematic review aimed to comprehensively survey the literature on expandable spinal fusion cages, discuss their differentiating factors, and identify gaps in the literature regarding these devices.
Purpose: To demonstrate the range of design features included in expandable interbody devices and identify which of these features are associated with improved surgical outcomes.
We describe an agent-based model purposed for social learning, which was developed by stakeholders, with the technical assistance of professional modelers, to facilitate stakeholder involvement in modeling issues related to the development of an adaptive environmental management plan for the Texas Gulf Coast (USA) estuaries. Stakeholders developed the model during six workshops that spanned a three-year period, and used the model to simulate the population dynamics (recruitment, growth, movement, and mortality) of blue crabs () in the Aransas and Copano Bays in response to various freshwater inflow and harvest scenarios. Results of scenarios representing normal, low, and high harvest levels indicated little effect on blue crab abundances, but harvests increased ≈75 % when harvest level was doubled and decreased ≈50 % harvest level was halved.
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