Publications by authors named "T C Muir"
This systematic review evaluated the effectiveness and side effects of various COVID-19 vaccines, with a focus on Trinidad and Tobago. The Pfizer-BioNTech and Moderna vaccines demonstrated the highest efficacy, particularly against COVID-19 variants, while Janssen and Sinopharm were comparatively less effective. mRNA vaccines, such as Pfizer-BioNTech and Oxford-AstraZeneca, were associated with more frequent and severe side effects, including soreness, fever, and cardiovascular issues.
View Article and Find Full Text PDFHistone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression. We previously demonstrated that serotonylation and dopaminylation of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states. Here we found that TG2 additionally functions as an eraser and exchanger of H3 monoaminylations, including H3Q5 histaminylation (H3Q5his), which displays diurnally rhythmic expression in brain and contributes to circadian gene expression and behaviour.
View Article and Find Full Text PDFArticle Synopsis
- - The new treatment method, Bleomycin ElectroScleroTherapy (BEST), uses bleomycin and electrical pulses to improve the treatment of vascular malformations, drawing parallels to electrochemotherapy for tumors.
- - A Current Operating Procedure (COP) is being developed to standardize BEST clinical practices, utilizing the Cliniporator device for electrical stimulation, and following European guidelines for safety and efficacy.
- - The protocol outlines specific requirements and recommends two technical approaches based on the type of lesion and available resources: one using ultrasound guidance and the other combining ultrasound with fluoroscopy.