Publications by authors named "T C Moore"

Aims: Peat is used as a major ingredient of growing media in horticulture. Peat extracted from bogs can be acidic and low in nutrient availability and is therefore mixed with liming agents, nutrients, surfactants, perlite and so on. This study aims to estimate the rates at which raw peat and the modified peat ('growing media') decompose to release carbon dioxide (CO), to estimate the release of carbon (C) from liming agents and to estimate how peat biogeochemistry is changed.

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The 22q11.2 Deletion Syndrome (22q11.2DS) is a multisystem genetic disorder with prominent sleep disturbances, neuropsychiatric conditions and neurocognitive challenges.

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Article Synopsis
  • Effective chronic disease prevention requires a systems approach that considers the complex factors influencing health outcomes.
  • The paper introduces the Participatory Implementation Systems Mapping (PISM) process, which integrates community collaboration and systems modeling to design tailored health interventions.
  • PISM comprises four phases: strategize, innovate, operationalize, and assess, and aims to enhance the implementation of interventions while addressing challenges like data availability and model complexity.
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Ebola and Marburg (EBOV and MARV) filoviral infections lead to fatal hemorrhagic fevers and have caused over 30 outbreaks in the last 50 years. Currently, there are no FDA-approved small molecule therapeutics for effectively treating filoviral diseases. To address this unmet medical need, we have conducted a systematic structural optimization of an early lead compound, -(4-(4-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-4-(morpholinomethyl)benzamide (), borne from our previously reported hit-to-lead effort.

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A 66-year-old female presented to the hospital for evaluation of multiple strokes over a three-month period. The patient underwent extensive testing to evaluate for autoimmune vasculitis and other hypercoagulable entities that were negative. Bone marrow and lymph node biopsies showed no evidence of lymphoma.

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