Publications by authors named "T C Mondin"
Background: Bipolar disorder (BD) has been associated with impaired cellular resilience. Recent studies have shown abnormalities in the unfolded protein response (UPR) in BD. The UPR is the cellular response to endoplasmic reticulum (ER) stress.
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- The study investigates how serum biomarkers and substance use predict the conversion from major depressive disorder (MDD) to bipolar disorder (BD) in adults.
- The conversion rate from MDD to BD was found to be 12.4%, with higher incidences among women and those with specific educational backgrounds and cocaine use.
- The analysis indicated a notable interaction between nerve growth factor (NGF) levels and cocaine use, suggesting these factors may contribute to the diagnostic conversion and, if untreated, could lead to poorer outcomes in BD prognosis.
The role of metabolic syndrome as a mediator in the relationship between CCL11 levels and the presence of a mood episode with mixed features in young adults with bipolar disorder.
Letícia Vasques Bender Natalia Wirowski Andressa Schneider Lobato Karen Jansen Taiane de Azevedo Cardoso Thaíse Campos Mondin
J Psychiatr Res
July 2024
Article Synopsis
- - Mixed features presentation in bipolar disorder (BD) is the most severe form, with increased serum levels of CCL11 contributing to cognitive decline and functional deterioration, a process known as neuroprogression.
- - Metabolic syndrome (MetS) is common in BD and could heighten inflammation and CCL11 levels, potentially worsening mood episodes with mixed features.
- - The study aimed to determine if MetS mediates the relationship between CCL11 levels and mixed mood episodes in BD, finding a trend suggesting MetS may play a significant role in accelerating neuroprogression in affected individuals.
Exploring protective factors in a high-risk subsample: the pivotal role of paternal support in preventing depression in a cohort of young adults.
Barbara Tietbohl-Santos Bruno Braga Montezano Taiane de Azevedo Cardoso Thaíse Campos Mondin Fernanda Pedrotti Moreira
Trends Psychiatry Psychother
April 2024
Article Synopsis
- Major depressive disorder (MDD) is a significant global issue, particularly concerning individuals with high-risk factors such as family history, past maltreatment, and socio-economic challenges.
- A study of 791 young adults examined various protective factors, including education, support systems, spirituality, and family dynamics to understand their impact on resilience to MDD over time.
- Findings reveal that paternal support notably lowers MDD and suicide attempt risks, and higher resilience correlates with lower depression scores, suggesting a shift towards positive prevention strategies focused on family involvement, especially fathers, is essential.