Validating a minipig model of reversible cerebral demyelination using human diagnostic modalities and electron microscopy.

Background: Inflammatory demyelinating diseases of the central nervous system, such as multiple sclerosis, are significant sources of morbidity in young adults despite therapeutic advances. Current murine models of remyelination have limited applicability due to the low white matter content of their brains, which restricts the spatial resolution of diagnostic imaging. Large animal models might be more suitable but pose significant technological, ethical and logistical challenges.

Design of topology optimized compliant legs for bio-inspired quadruped robots.

Robotic legs are an important component of the quadruped robot for achieving different motion gaits. Although the conventional rigid-link-based legs can generally perform robust motions, they still have the issues with poor sealing when operating in complex and liquid terrains. To cope with this problem, fully compliant legs with monolithic structure have been introduced in recent years to improve the system compactness and structural compliance of quadruped robots.

Concept and first Implementation of an intracochlearly navigated Electrode Array for Cochlear Implantation.

Cochlear implants (CI) are an established treatment for people with deafness or severe hearing loss. To restore patients' hearing an electrode array (EA) of the CI is inserted into the cochlea to stimulate the auditory nerve. Thereby, the exact positioning and gentle insertion of the EA is crucial for optimal hearing perception outcome.

Cruciate-Ligament-Inspired Compliant Joints: Application to 3D-Printed Continuum Surgical Robots.

The rapid development of additive manufacturing technology makes it possible to fabricate a patient-specific surgical robot in a short time. To simplify the assembly process of the printed robotic system, compliant-joint-based monolithic structures are often used as substitutes for rigid-link mechanisms to realize flexible bending. In this paper, we introduce a cruciate-ligament-inspired compliant joint (CLCJ) to improve the bending stability of the 3D-printed continuum surgical robots.

Design of Bionic Prosthetic Fingers Using 3D Topology Optimization.

Compliant mechanisms are frequently used in the design of prosthetic fingers since their monolithic structure and flexible movement are quite similar to the biological human fingers. However, the design of compliant prosthetic fingers is not easy, as the conventional rigid-link-based mechanism theory cannot be directly applied. In this paper, we introduce a 3D topology optimization based design framework to simplify the synthesis process of bionic compliant prosthetic fingers.