Biocatalytic oxyfunctionalization of unsaturated fatty acids to oxygenated chemicals via hydroxy fatty acids.

The selective oxyfunctionalization of unsaturated fatty acids is difficult in chemical reactions, whereas regio- and stereoselective oxyfunctionalization is often performed in biocatalytic synthesis. Fatty acid oxygenases, including hydratases, lipoxygenases, dioxygenases, diol synthases, cytochrome P450 monooxygenases, peroxygenases, and 12-hydroxylases, are used to convert C16 and C18 unsaturated fatty acids to diverse regio- and stereoselective mono-, di-, and trihydroxy fatty acids via selective oxyfunctionalization. The formed hydroxy fatty acids or hydroperoxy fatty acids are metabolized to industrially important oxygenated chemicals such as lactones, green leaf volatiles, and bioplastic monomers, including ω-hydroxy fatty acids, α,ω-dicarboxylic acids, and fatty alcohols, by biocatalysts.

Longitudinal determinants of thriving in Puerto Rican climate crisis migrants on the U.S. mainland: A structural equation model.

Climate-related disasters pose significant risks to mental health and well-being globally. Individuals from disaster-prone regions, such as Puerto Rico, are at even greater risk. The devastating effects of recurrent hurricanes, compounded with pre-existing structural disparities (e.

Beyond consciousness: Ethical, legal, and social issues in human brain organoid research and application.

This study aims to provide a comprehensive review of the ethical, legal and social issues in human brain organoid research, with a view to different types of research and applications: in vitro research, transplantation into non-human animals, and biocomputing. Despite the academic and societal attention on the possibility that human brain organoids may be conscious, we have identified diverse issues in human brain organoid research and applications. To guide the complex terrain of human brain organoid research and applications, a multidisciplinary approach that integrates ethical, legal, and social perspectives is essential.

Stabilizing Polyoxometalate for Enhanced OER Performance Using a Porous Manganese Oxide Support.

The oxygen evolution reaction (OER) is a critical challenge in electrocatalytic water splitting, hindered by high energy demands and slow kinetics. Polyoxometalates (POMs), recognized for their unique redox capabilities, structural archetypes, and molecular precision, are promising candidates for the oxygen evolution reaction (OER). Yet, their application is hindered by high water solubility, causing rapid degradation and efficiency loss under harsh OER conditions.

Correction: Venous congestion affects neuromuscular changes in pigs in terms of muscle electrical activity and muscle stiffness.

[This corrects the article DOI: 10.1371/journal.pone.