A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.

Background: Atopic dermatitis (AD) is a common inflammatory skin disease. Previous studies have revealed shared genetic determinants among different inflammatory disorders, suggesting that markers associated with immune-related traits might also play a role in AD.

Objective: We sought to identify novel genetic risk factors for AD.

The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever.

In a genome-wide association study, a common variant on chromosome 11q13.5 (rs7927894[T]) has been identified as a susceptibility locus for eczema. We aimed to analyze the effect of this risk variant on asthma and hay fever and to determine its impact on the general population level in over 9300 individuals of the prospectively evaluated Avon Longitudinal Study of Parents and Children birth cohort.

Predicting the segregation profile of the Pt25Rh75(100) surface from first-principles.

The segregation profile of the Pt(25)Rh(75)(100) surface is studied by the combination of density functional theory calculations with the cluster-expansion method and Monte Carlo simulations. We construct the stability diagram for the surface layers, which allows the prediction of the most stable atomic configuration for a given average concentration in those layers. On this basis, we apply the cluster-expansion Hamiltonian in grand-canonical Monte Carlo simulations for the prediction of the temperature-dependent concentration profile.

Nitric-oxide photorelease and photoinduced linkage isomerism on solid [Ru(NO)(terpy)(L)]BPh4 (L = glycolate dianion).

Following photoexcitation at 80 K, two phenomena were detected on solid samples of a single substance, the tetraphenylborate of the [Ru(NO)(terpy)(L)](+) cation (terpy = 2,2':6',2''-terpyridine, L = glycolate(2-) [oxyacetate]): the formation of photoinduced linkage isomers of the nitrosyl ligand, and photorelease of nitric oxide. Populations of about 9% and 4% were measured for the photoinduced isonitrosyl (MS1) and the side-on nitrosyl (MS2) linkage isomers, respectively. At room temperature, NO release in the solid was observed as the only reaction.