Intraoperative Management of Parathyroid Glands and Long-Term Outcome of Parathyroid Function Following Total Thyroidectomy.

In situ preservation is the primary strategy to preserve parathyroid gland (PG) function during thyroid surgery, while autotransplantation is used when inadvertent removal or devascularization occurs. Deciding on the optimal approach intraoperatively for exposed PGs remains challenging. This study evaluates intraoperative PG management strategies and long-term outcomes of PG function following total thyroidectomy.

Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE.

Recent advances in spatial transcriptomics (ST) technologies have transformed our ability to profile gene expression while retaining the crucial spatial context within tissues. However, existing ST platforms suffer from high costs, long turnaround times, low resolution, limited gene coverage, and small tissue capture areas, which hinder their broad applications. Here we present iSCALE, a method that predicts super-resolution gene expression and automatically annotates cellular-level tissue architecture for large-sized tissues that exceed the capture areas of standard ST platforms.

Reliability Improvement of High Mobility Oxide TFTs Based on Hydrogen-Resistant PEALD AlO Gate Insulators Grown with NO Plasma.

High quality aluminum oxide (AlO) dielectric films were fabricated based on plasma-enhanced atomic layer deposition (PEALD) and applied as gate insulators in high mobility oxide thin film transistors (TFTs). NO plasma was used as the oxidizing reactant during the PEALD process, which resulted in the incorporation of nitrogen in the growing layers. The nitrogen content in AlO could be adjusted by varying the NO plasma power between 100 and 250 W.

Identification of Hub Genes Involved in Early-onset Schizophrenia: From Genetic Susceptibility to Predicted Regulated Gene Expression.

Background: Despite a high heritability of schizophrenia (SZ), only limited variance was attributed to gene loci or the polygenic risk score in genome-wide association studies (GWAS). Early-onset SZ, a more homogeneous SZ subtype, may aid in bridging the genotype-phenotype gap and the identification of its hub genes is critical for early intervention in clinical practice. We aimed to examine the gene expression risk score (GeRS) in patients from both multiplex and simplex families to identify hub genes for early-onset SZ, and perform enrichment analysis to understand the biological functions of the hub genes.