Discovery of mono-ADP ribosylating toxins with high structural homology to Pseudomonas exotoxin A.

Mono-ADP-ribosyl transferase (mART) proteins are secreted virulence factors produced by several human pathogens, the founding member being diphtheria toxin (DT). Pseudomonas aeruginosa can also secrete a mART toxin, known as exotoxin A (PE), but with an organization of its three functional domains (receptor, translocation, and enzymatic elements) that is opposite to DT. Two additional PE-like toxins (PLTs) have been identified from Vibrio cholerae and Aeromonas hydrophila, suggesting more PLT family members may exist.

'They made a hard day feel a little easier': Patients' experiences of an integrated crisis response following recent sexual assault.

Background And Objectives: Sexual assault services in New South Wales (NSW), Australia provide crisis support from a counsellor working with a forensically trained doctor, or nurse, providing medical care and the option of forensic examination. The aim of this paper is to gain an understanding of the experience of recent sexual assault victim-survivors who accessed one of these 24-hour services.

Method: A feedback questionnaire was offered to victim-survivors on completion of the integrated crisis response.

Combined clinoptilolite and Fe(O)OH for efficient removal of Cu(II) and Pb(II) with enhanced solid-liquid separation.

Unlabelled: This study investigated combining fine clinoptilolite with iron hydroxide coagulant, as a cost-effective, dual-purpose flocculant for enhanced removal of Pb⁺ or Cu⁺ ions, along with the solid-liquid separation and physicochemical analysis. For the clinoptilolite, adsorption kinetics fitted a pseudo-second-order (PSO) rate model with higher rate constants for Pb, while equilibrium adsorption data fitted the Langmuir monolayer model, with similar at 18.8 mg/g for Pb and 18.

Understanding and experience of the medical forensic examination after sexual assault: protocol for a mixed methods study.

Introduction: Victim survivors of sexual assault can potentially benefit from attending a medical forensic examination when it is provided by an integrated, multidisciplinary team in a trauma-informed way. Instead of being retraumatising, the examination is intended to be reassuring.

Methods And Analysis: This study will explore the understanding and experience of the medical forensic examination from a population of patients who attend after a recent sexual assault.

Social Workers' Attitudes and Beliefs about MDMA-Assisted Therapy for Adolescents with PTSD.

Given the widespread interest and ongoing study on MDMA-assisted therapy (MDMA-AT) for PTSD, its implications for unique populations-such as adolescents-require further understanding. Social workers will likely play a crucial role in the potential implementation of this intervention, but their perspectives remain unknown. The study includes 222 social workers randomized to read one of two vignettes about MDMA-AT or selective serotonin reuptake inhibitor-assisted therapy (SSRI-AT) for treating adolescent treatment-resistant PTSD.