Publications by authors named "T C Heineman"
Purpose: Evaluate the effectiveness of the clinical decision support tools (CDSTs), POC Advisor (POCA), and Modified Early Warning System (MEWS) in identifying sepsis risk and influencing time to treatment for inpatients, comparing their respective alert mechanisms.
Methods: This study was conducted at two academic university medical center hospitals. Data from adult inpatients in medical-surgical and telemetry units were analyzed from January 1, 2020, to December 31, 2020.
Background: We previously reported activity of pelareorep, pembrolizumab and chemotherapy. Patients developed new T-cell clones and increased peripheral T-cell clonality, leading to an inflamed tumour. To evaluate a chemotherapy-free regimen, this study assesses if pelareorep and pembrolizumab has efficacy by inducing anti-tumour immunological changes (NCT03723915).
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- - Fanconi anaemia (FA) is a genetic condition that makes DNA repair faulty, leading to chromosome breakage and a significantly higher risk of specific cancers such as head and neck, esophageal, and anogenital squamous cell carcinomas compared to the general population.
- - Research reveals that squamous cell carcinomas from FA patients exhibit numerous structural variants, which include small deletions and complex rearrangements, often occurring alongside loss of the TP53 gene but not related to HPV infections.
- - The instability caused by FA may trigger processes like epithelial-to-mesenchymal transition and heightened inflammatory signaling in skin cells, highlighting the potential for FA's unique genomic issues to inform understanding of sporadic HNSCC linked to tobacco and alcohol
Most gastrointestinal (GI) cancers have microsatellite-stable (MSS) tumors, which have an immunologically 'cold' phenotype with fewer genetic mutations, reduced immune cell infiltration and downregulated immune checkpoint proteins. These attributes make MSS tumors resistant to conventional immunotherapy including checkpoint blockade therapy. Pelareorep is a naturally occurring, nongenetically modified reovirus.
View Article and Find Full Text PDFAdjuvanted recombinant zoster vaccine in adult autologous stem cell transplant recipients: polyfunctional immune responses and lessons for clinical practice.
Hum Vaccin Immunother
November 2021
Immunocompromised individuals, particularly autologous hematopoietic stem cell transplant (auHSCT) recipients, are at high risk for herpes zoster (HZ). We provide an in-depth description of humoral and cell-mediated immune (CMI) responses by age (protocol-defined) or underlying disease (post-hoc) as well as efficacy by underlying disease (post-hoc) of the adjuvanted recombinant zoster vaccine (RZV) in a randomized observer-blind phase III trial (ZOE-HSCT, NCT01610414). 1846 adult auHSCT recipients were randomized to receive a first dose of either RZV or placebo 50-70 days post-auHSCT, followed by the second dose at 1-2 months (M) later.
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