Reproducibility and flexibility of monoclonal antibody production with .

The ongoing SARS-CoV-2 coronavirus pandemic of 2020-2021 underscores the need for manufacturing platforms that can rapidly produce monoclonal antibody (mAb) therapies. As reported here, a platform based on produced mAb therapeutics with high batch-to-batch reproducibility and flexibility, enabling production of 19 different mAbs of sufficient purity and safety for clinical application(s). With a single manufacturing run, impurities were effectively removed for a representative mAb product (the ZMapp component c4G7).

Regional Interdependence and the Role of the Lower Body in Elbow Injury in Baseball Players: A Systematic Review.

Background: Elbow injuries are exceedingly common in baseball players. Previous studies have identified that upper extremity strength and range of motion deficits pose a risk for these injuries, but few studies have examined the effect of lower extremity deficits. Given the role of the lower extremity in the kinetic chain of the baseball throwing motion, lower body deficits may affect the kinematics of the upper extremity and play a role in the elbow injury of baseball players.

Frequency-based Dissociation of Symbolic and Nonsymbolic Numerical Processing during Numerical Comparison.

Recent evidence suggests that during numerical calculation, symbolic and nonsymbolic processing are functionally distinct operations. Nevertheless, both roughly recruit the same brain areas (spatially overlapping networks in the parietal cortex) and happen at the same time (roughly 250 msec poststimulus onset). We tested the hypothesis that symbolic and nonsymbolic processing are segregated by means of functionally relevant networks in different frequency ranges: high gamma (above 50 Hz) for symbolic processing and lower beta (12-17 Hz) for nonsymbolic processing.

Return to Play After an Anterior Cruciate Ligament Injury: Prioritizing Neurological and Psychological Factors of the Decision-Making Algorithm.

Soccer players recovering from anterior cruciate ligament (ACL) injuries have better options for treatment today than they did 25 years ago. Surgical techniques have improved, and rehabilitation protocols have evolved considerably. Although the rehabilitation community is doing a better job of treating this patient population, the evidence does demonstrate that both re-injury and return- to-play (RTP) rates are still suboptimal.

Symbolic and non symbolic numerical representation in adults with and without developmental dyscalculia.

Background: The question whether Developmental Dyscalculia (DD; a deficit in the ability to process numerical information) is the result of deficiencies in the non symbolic numerical representation system (e.g., a group of dots) or in the symbolic numerical representation system (e.