FON: An Innovative Fluorinated Group via Hydroetherification-Type Reactivity.

An efficient strategy for preparing the novel -difluoroalkylhydroxylamine fluorinated functional group, coined FON, is reported. This analogue of medicinally important β-phenethyl ether scaffolds in uniting -difluoro and N-O moieties is synthesized in one step via chemo- and regioselectivity metal-free hydroetherification-type additions. As shown, this unique mode of reactivity is realized for a diverse substrate scope and applied to gram-scale synthesis and site-selective deuterium incorporation.

The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma.

The aim of this study is to investigate the prognostic role of body mass index (BMI) on survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, and we stratified the results according to cancer site.

Cross-ancestral GWAS identifies 29 novel variants across Head and Neck Cancer subsites.

In this multi-ancestry genome-wide association study (GWAS) and fine mapping study of head and neck squamous cell carcinoma (HNSCC) subsites, we analysed 19,073 cases and 38,857 controls and identified 29 independent novel loci. We provide robust evidence that a 3' UTR variant in (rs78378222, T>G) confers a 40% reduction in odds of developing overall HNSCC. We further examine the gene-environment relationship of and variants demonstrating their effects act through both smoking and alcohol use.

Polymer-supported strong Lewis acid phosphonium cation catalysis applied to sydnone synthesis.

Organochlorophosphonium P(V) species are strong Lewis acids deriving from a low-lying σ* orbital at P opposite to Cl. Herein, applying this strong acidity to heterogenous reactivity, we introduce polymer-supported phosphorus(V)-mediated Lewis acid catalysis. Key to this innovation is the use of a recyclable solid support Merrifield resin P(V) Lewis acid catalyst with demonstrated utility for the one-pot synthesis of sydnones.