Publications by authors named "T Burdon"
Article Synopsis
- Wildlife biodiversity helps keep ecosystems healthy and strong.
- Scientists study this diversity to learn more about life and how it started.
- Due to the rapid loss of various species, immediate action is needed from conservationists, and new techniques like stem cell technologies could help protect animal diversity.
Article Synopsis
- The p75NTR neurotrophin receptor plays both helpful and harmful roles in nerve cell survival, but studying its effects has been complicated by the presence of different forms in mouse models.* -
- Researchers created a mutant rat that completely lacks the p75NTR protein using advanced genetic techniques, allowing for a clearer understanding of its function.* -
- These p75NTR-deficient rats are healthy and show no major brain structure changes, indicating that p75NTR is not essential for normal growth, but they offer a valuable model for exploring p75NTR's role in injury and repair processes.*
Article Synopsis
- The study focuses on understanding the surface molecules of bovine alveolar macrophages (AMs) that protect against pathogens like Mycobacterium bovis, responsible for bovine tuberculosis.
- Researchers used flow cytometry to analyze bronchoalveolar lavage samples from calves, revealing specific expression patterns of various immune cell molecules on bovine AMs.
- The findings identified two distinct subsets of bovine AMs based on CD163 expression, with implications for their roles in immune response during infections.
Background: Quadricuspid aortic valve (QAV) is a rare congenital anomaly characterized by the presence of four cusps instead of the usual three. It is estimated to occur in less than 0.05% of the population, with Type A (four equal-sized leaflets) accounting for roughly 30% of QAV subtypes.
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- Recent evidence challenges the previous belief that MeCP2 contributes to heterochromatin formation through liquid-liquid phase separation.
- Studies show that MeCP2 localization occurs independently of heterochromatin organization, as MeCP2 foci remain intact even when heterochromatin is disrupted.
- The research also indicates that animal models, especially mice, are not typical, as most mammals, including humans, show a diffuse distribution of MeCP2, which is influenced mainly by global DNA methylation rather than the formation of condensates.