Publications by authors named "T Brousseau"
Article Synopsis
- The study investigates the effectiveness of a rapid immunoassay technique (Snibe) versus mass spectrometry (LC-MS/MS) in measuring plasma homocysteine levels, particularly in patients with nitrous oxide abuse.
- Significant elevations in plasma homocysteine were found in nitrous oxide abusers, with the immunoassay delivering faster results, although it generally underestimated high levels compared to LC-MS/MS.
- The findings highlight the need for the immunoassay as a quick initial screening tool, while still recommending confirmation with LC-MS/MS for accurate diagnosis of conditions associated with oxidative stress.
In France, both students from medicine and pharmacy background can have access to the residency in laboratory medicine (LM). The current curriculum of LM residency includes an early choice of option after the first two years of residency, which subsequently guides the rest of the training. This study aimed to analyze these choice and motivational factors, since its implementation in 2017.
View Article and Find Full Text PDF(1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of routine laboratory parameters, widely used in practice and easily available, with the severity and progression of SSc.
View Article and Find Full Text PDFOwing to their ease of use, glucose meters are frequently used in research and medicine. However, little is known of whether other non-glucose molecules, besides vitamin C, interfere with glucometry. Therefore, we sought to determine whether other antioxidants might behave like vitamin C in causing falsely elevated blood glucose levels, potentially exposing patients to glycemic mismanagement by being administered harmful doses of glucose-lowering drugs.
View Article and Find Full Text PDFSevere SARS-CoV-2 patients develop a higher specific T-cell response.
Clin Transl Immunology
December 2020
Objectives: Assessment of the adaptive immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for studying long-term immunity and vaccine strategies. We quantified IFNγ-secreting T cells reactive against the main viral SARS-CoV-2 antigens using a standardised enzyme-linked immunospot assay (ELISpot).
Methods: Overlapping peptide pools built from the sequences of M, N and S viral proteins and a mix (MNS) were used as antigens.