Publications by authors named "T Brodowicz"
Article Synopsis
- E-TRAB was a study aimed at evaluating the value of geriatric assessments in older patients with soft tissue sarcoma (STS) receiving trabectedin as a first-line treatment.
- The study involved 69 older patients, with an average age of 78, and assessed their overall survival, quality of life, and treatment-related toxicities using various assessment tools.
- Findings indicated that while trabectedin was generally safe, certain predictors from the geriatric assessments, such as the Long Timed Up and Go test and CARG score, were linked to outcomes like overall survival and hospitalizations related to treatment side effects.
Background/aim: Soft tissue sarcomas are rare and heterogenous malignancies with high recurrence rates following resection and a poor prognosis in advanced stages. Eribulin is used in metastatic soft tissue sarcoma patients, who have failed first line chemotherapy and has been approved for patients with pretreated advanced liposarcoma (LPS) in the United States and Europe following the publication of data of a phase III trial. In addition, no data are available for eribulin as postoperative treatment after potentially curative surgery.
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- * Conducted on 158 patients treated at the Medical University of Vienna, the research utilized statistical methods like Kaplan-Meier curves and Cox proportional hazard models to analyze data collected from 1994 to 2021.
- * Findings showed that higher fibrinogen levels were associated with poorer overall survival rates, with a significant hazard ratio indicating increased mortality risk as fibrinogen levels rose; this remained true even after adjusting for tumor stage.
Background: Owing to the rarity and heterogeneity in biology and presentation, there are multiple areas in the diagnosis, treatment and follow-up of soft tissue sarcoma (STS), with no, low-level or conflicting evidence.
Methods: During the first Consensus Conference on the State of Science in Sarcoma (CSSS), we used a modified Delphi process to identify areas of controversy in the field of sarcoma, to name topics with limited evidence-based data in which a scientific and knowledge gap may remain and a consensus statement will help to guide patient management. We determined scientific questions which need to be addressed in the future in order to generate evidence and to inform physicians and caregivers in daily clinical practice in order to improve the outcomes of patients with sarcoma.
Localised Synovial Sarcoma in Adolescents and Young Adults Versus Adults - Is There a Difference in Outcome?
Clin Oncol (R Coll Radiol)
March 2023
Aims: Synovial sarcomas are a rare subgroup of soft-tissue sarcoma arising in adolescents and young adults (AYA) and in adult patients. The objective of our analysis was to investigate the outcomes and potential differences of AYA versus adult patients with initially localised disease.
Materials And Methods: In total, 51 patients (25 AYA and 26 adult) were identified and evaluated in this retrospective single centre analysis.