Publications by authors named "T Boyles"
Importance: Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19.
Objective: To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia.
Design, Setting, And Participants: This multicenter, phase 3, placebo-controlled, double-blinded randomized clinical trial was conducted at 41 US sites and 21 international sites between November 17, 2021, and September 27, 2023; the last follow-up visit was December 31, 2023.
Article Synopsis
- There is currently no fast and accurate test for diagnosing tuberculous meningitis (TBM), which often delays treatment; this study aimed to create a better diagnostic tool by using a variety of data from past studies across different populations.* -
- The research involved 3,761 participants from 14 studies, identifying key predictive factors like cerebrospinal fluid glucose and HIV status, and analyzed the data using techniques like logistic regression and random forest regression.* -
- The resulting mobile app for TBM diagnosis shows promising accuracy, with further validation needed to confirm its effectiveness in diverse clinical settings.*