Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We studied this relationship using the polar organizing protein Z (PopZ) as a model system, revealing how its material properties and cellular function depend on its ultrastructure.
View Article and Find Full Text PDFIntroduction: Survivors of critical illness and their caregivers are at risk for long-term cognitive, physical and psychiatric impairments known as post-intensive care syndrome (PICS) and PICS-family, respectively. This study will assess the feasibility of a randomised controlled trial (RCT) evaluating an intensive care unit (ICU) follow-up care bundle versus standard-of-care for ICU patients and their caregivers.
Methods And Analysis: This is a single-centre feasibility study.
We show that it is possible to design corrugated waveguides where phase and group velocities coincide at an inflection point of the dispersion relation, thereby allowing an extended regime of interaction with a charge particle beam. This provides a basis for designing travelling slow-wave structures with a broadband interaction between relativistic charged particle beams and propagating terahertz waves allowing an energy exchange between beam and wave, amplifying terahertz radiation. We employ Fourier-Mathieu expansion, which gives approximate analytic solutions to Maxwell equations in a corrugated waveguide with periodically undulating cross-section.
View Article and Find Full Text PDFThe inorganic biopolymer polyphosphate (polyP) occurs in all domains of life and affects myriad cellular processes. A longstanding observation is polyP's frequent proximity to chromatin, and, in many bacteria, its occurrence as magnesium (Mg)-enriched condensates embedded in the nucleoid region, particularly in response to stress. The physical basis of the interaction between polyP, DNA and Mg, and the resulting effects on the organization of the nucleoid and polyP condensates, remain poorly understood.
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