Publications by authors named "T Bowen"
Article Synopsis
- Researchers have identified a specific circular RNA, circDdb1, that plays a significant role in causing skeletal muscle atrophy, which is often linked to aging and various diseases.
- CircDdb1 levels are significantly increased during muscle atrophy, and adding it artificially leads to more atrophy, whereas its inhibition can prevent muscle loss caused by different factors.
- The study also finds that circDdb1 regulates protein translation via its interaction with eukaryotic elongation factor 2 (eEF2) and suggests that targeting circDdb1 could serve as a new therapeutic approach to combat muscle atrophy.
Postnatal kidney growth is substantial and involves expansion in kidney tubules without growth of new nephrons, which are the functional units of the kidney. Proliferation and differentiation pathways underpinning nephron elongation are not well defined. To address this, we performed sequential characterization of mouse kidney transcriptomics at the single cell level.
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- Women with heart failure and reduced ejection fraction (HFrEF) experience more severe symptoms and a lower quality of life than men, potentially linked to differences in skeletal muscle pathology between the sexes.
- A study analyzed muscle biopsies from men and women with HFrEF, revealing significant differences in gene expression, muscle fiber types, and inflammatory markers, including 5629 differentially expressed genes.
- Results indicated that men had more proatrophic gene expression and muscle abnormalities, while women displayed a pro-oxidative muscle phenotype with greater muscle capillarity and higher density of type I fibers.