Publications by authors named "T Bouwmeester"
Aims: Cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) are measures of autonomic cardiac control and are associated with hypertension. However, their value in predicting new-onset hypertension and changes in systolic blood pressure (SBP) remains elusive.
Methods: We used longitudinal data of participants with- and without a history of cardiovascular disease from the HEalthy Life In an Urban Setting (HELIUS) study.
Article Synopsis
- - Sickle cell disease (SCD) is a serious inherited condition caused by a mutation in the β-hemoglobin gene, and increasing fetal hemoglobin (HbF) levels can help reduce complications.
- - Researchers discovered two small molecules, dWIZ-1 and dWIZ-2, that act as molecular glue degraders to induce HbF by targeting a previously unrecognized repressor, the WIZ transcription factor.
- - These compounds effectively triggered HbF production in animal models, suggesting that targeting WIZ for degradation offers a promising and accessible new treatment approach for SCD.
Article Synopsis
- The YAP/Hippo pathway regulates organ growth and helps maintain stem cell function, with LATS kinases playing a critical role by inactivating YAP.
- A new small-molecule inhibitor, NIBR-LTSi, has been developed that selectively targets LATS kinases, activating YAP signaling and promoting tissue regeneration in laboratory settings.
- While NIBR-LTSi shows promise by enhancing liver regeneration and supporting stem cell characteristics, prolonged use may lead to excessive cell proliferation and dedifferentiation, which could limit its therapeutic benefits.
Background: Hypertension can be classified into different phenotypes according to systolic and diastolic blood pressure (BP). In younger adults, these phenotypical differences have different prognostic value for men and women. However, little is known about sex differences in the natural course of different BP phenotypes over time.
View Article and Find Full Text PDFA limited understanding of the pathology underlying chronic wounds has hindered the development of effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate the molecular composition of various common chronic ulcer types to facilitate drug discovery strategies. We conducted a comprehensive analysis of leg ulcers (LUs), encompassing venous and arterial ulcers, foot ulcers (FUs), pressure ulcers (PUs), and compared them with surgical wound healing complications (WHCs).
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