Publications by authors named "T Boutin"
Purpose: To validate a French version of the Visual Function and Corneal Health Status (V-FUCHS) instrument in Fuchs endothelial corneal dystrophy (FECD) and to correlate questionnaire scores with objective measurements of best-corrected visual acuity (BCVA) and intraocular straylight.
Methods: The original V-FUCHS 15-item instrument was designed to assess VA and glare in patients with FECD. It was translated from English to French and back translated to English by independent translators.
Article Synopsis
- - Gout is a chronic condition caused by the immune system's reaction to monosodium urate crystals due to high uric acid levels, and recent research sheds light on its inflammatory mechanisms.
- - A large genome-wide association study (GWAS) involving 2.6 million people identified 377 genetic locations linked to gout, with a focus on 149 new loci related to urate and gout inflammation.
- - The study also pinpointed candidate genes influencing the inflammatory response in gout, including those affecting NLRP3 inflammasome activity, and suggests a potential causal role of specific genetic factors in developing the disease.
Article Synopsis
- * The research showed that individuals with high polygenic risk scores have significantly higher blood pressure (almost 17 mmHg more) and over seven times the risk of developing hypertension compared to those with low scores.
- * Incorporating these genetic risk scores into hypertension prediction models improved their accuracy, and excitingly, similar genetic associations were found in a large African-American sample, underscoring the potential of these findings for precision health initiatives.
Article Synopsis
- A genome-wide association study was conducted on thyroid function, analyzing data from up to 271,040 European individuals, focusing on hormones like TSH, FT4, and T3.
- The study identified 259 significant genetic associations for TSH (61% were novel), and notable findings for FT4 and T3, indicating that specific genes influence thyroid hormone levels and metabolism.
- The research findings enhance the understanding of thyroid hormone roles and suggest that variations in thyroid function may impact various health conditions including cardiovascular issues, autoimmune diseases, and cancer.