Publications by authors named "T Boudier"
Background: Dendritic spines are tiny protrusions found along the dendrites of neurons, and their number is a measure of the density of synaptic connections. Altered density and morphology is observed in several pathologies, and spine formation as well as morphological changes correlate with learning and memory. The detection of spines in microscopy images and the analysis of their morphology is therefore a prerequisite for many studies.
View Article and Find Full Text PDFArticle Synopsis
- Orphan nuclear receptors (NRs) like COUP-TF1 and others are linked to telomerase-negative cancers that use an alternative mechanism (ALT) to maintain their telomeres, but their exact role in activating ALT is unknown.
- The study shows that when these orphan NRs are attached to telomeres in human fibroblasts, they trigger the formation of specific structures (APBs) and activate ALT processes, indicating that they can induce ALT from scratch.
- Overexpression of orphan NRs enhances ALT activity, while their removal decreases it, showing their critical role in promoting ALT, potentially offering a target for new therapies using agents like arsenic trioxide to inhibit ALT in cancer cells.
Article Synopsis
- Myelin plasticity is essential for learning and memory in the adult brain, and any loss or alteration can impair brain function.
- In a mouse model study, researchers found that while spontaneous remyelination can occur after demyelination, the newly formed myelin often does not match the original structure, impacting cognitive function.
- The study revealed that even after remyelination, there were long-term cognitive deficits, including issues with memory and flexibility, likely due to changes in myelin in key brain areas like the medial prefrontal cortex and hippocampus.
Monocytes activated by pro-inflammatory signals adhere to the vascular endothelium and migrate from the bloodstream to the tissue ultimately differentiating into macrophages. Cell mechanics and adhesion play a crucial role in macrophage functions during this inflammatory process. However, how monocytes change their adhesion and mechanical properties upon differentiation into macrophages is still not well understood.
View Article and Find Full Text PDFCardioVinci: building blocks for virtual cardiac cells using deep learning.
Philos Trans R Soc Lond B Biol Sci
November 2022
Advances in electron microscopy (EM) such as electron tomography and focused ion-beam scanning electron microscopy provide unprecedented, three-dimensional views of cardiac ultrastructures within sample volumes ranging from hundreds of nanometres to hundreds of micrometres. The datasets from these samples are typically large, with file sizes ranging from gigabytes to terabytes and the number of image slices within the three-dimensional stack in the hundreds. A significant bottleneck with these large datasets is the time taken to extract and statistically analyse three-dimensional changes in cardiac ultrastructures.
View Article and Find Full Text PDF