Publications by authors named "T Bouderlique"
Article Synopsis
- BTK is essential for B-cell survival, and its inhibitors are effective treatments for B-cell malignancies, with phosphorylation of specific tyrosine residues playing key roles in its activity.
- Through genetic engineering, researchers created mice with a Y223F mutation to investigate the role of the Y223 phosphorylation site, but found no significant differences in immune responses compared to wild-type mice.
- These results challenge the long-standing belief that Y223 phosphorylation is critical for BTK function, indicating it may not be necessary for the enzyme's activity.
In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and mammals. Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans.
View Article and Find Full Text PDFArticle Synopsis
- Tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML) but do not eliminate leukemia-initiating stem cells (LSCs), leading to persistent disease and relapse.
- The study investigates bone marrow (BM) niches in CML patients and finds differences in niche composition and function, revealing that mesenchymal stem cells from CML patients better support both normal and CML cells.
- CXCL14 was identified as a key factor, as its loss in CML BM niches was linked to maintaining LSCs; restoring CXCL14 showed potential in inhibiting LSC growth and improving responses to TKIs like imatinib.
Schwann cell precursors (SCPs) are nerve-associated progenitors that can generate myelinating and non-myelinating Schwann cells but also are multipotent like the neural crest cells from which they originate. SCPs are omnipresent along outgrowing peripheral nerves throughout the body of vertebrate embryos. By using single-cell transcriptomics to generate a gene expression atlas of the entire neural crest lineage, we show that early SCPs and late migratory crest cells have similar transcriptional profiles characterised by a multipotent "hub" state containing cells biased towards traditional neural crest fates.
View Article and Find Full Text PDF