Publications by authors named "T Bottiglieri"
Scope: Human milk (HM) is rich in bioactive compounds and essential nutrients. While research has focused on lipids, minerals, immune markers, microbiota, and oligosaccharides, specific metabolites are less studied. This study uses targeted metabolomics to identify and quantify metabolites in HM and explores the impact of perinatal and dietary factors on the metabolomic profile.
View Article and Find Full Text PDFMetabolomics and lipidomics are pivotal in understanding phenotypic variations beyond genomics. However, quantification and comparability of mass spectrometry (MS)-derived data are challenging. Standardised assays can enhance data comparability, enabling applications in multi-center epidemiological and clinical studies.
View Article and Find Full Text PDFBackground: There is no clinically relevant serological marker for the early detection of oesophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's oesophagus (BE).
Objective: To develop and test a blood-based assay for EAC and BE.
Design: Oesophageal MicroRNAs of BaRRett, Adenocarcinoma and Dysplasia () was a large, international, multicentre biomarker cohort study involving 792 patient samples from 4 countries (NCT06381583) to develop and validate a circulating miRNA signature for the early detection of EAC and high-risk BE.
Objectives: Nearly 3 million children participate in youth soccer annually in the United States. Popularity of youth soccer within recent years has prompted investigation describing youth-soccer concussion trends presenting to United States emergency departments (EDs).
Methods: Data from National Electronic Injury Surveillance System were analyzed for soccer players 2-18 years old sustaining concussions from January 2013 to December 2022.
Article Synopsis
- Homocystinuria (HCU) is caused by a deficiency in the enzyme cystathionine beta-synthase (CBS), leading to high levels of homocysteine in the body; it can be managed through a special diet and vitamin B supplementation, but there is currently no cure.
- Recent research shows that enzyme replacement therapy (ERT) using human CBS can significantly lower homocysteine levels in mice, though it doesn't fully normalize them, prompting further investigation into how ERT works.
- The study found that reducing homocysteine levels enhances CBS function, and using biological reductants like N-acetylcysteine can improve the effectiveness of CBS-based ERT, offering new ways to tackle H