Publications by authors named "T Borsello"
Article Synopsis
- * The study, funded by the Italian Ministry of Health, aims to explore how inflammation contributes to depression onset, treatment resistance, and related health issues through various scientific analyses and human cohorts.
- * Over two years, the research will enhance understanding of inflammation's role in MDD and related disorders, potentially leading to new personalized treatment strategies.
Article Synopsis
- The c-Jun N-terminal kinases (JNKs) are proteins activated by stress that can negatively affect neuron function and survival, particularly in the context of Alzheimer's disease (AD).
- A study on 5xFAD mice, which model human AD, revealed significant JNK activation at 3.5 months that correlated with changes in neuron structure and memory loss.
- These results suggest that targeting JNK might be a promising strategy for developing treatments aimed at preventing synaptic impairment in the early stages of AD.
Introduction: Autism spectrum disorders (ASD) are the most prevalent neurobiological disorders in children. The etiology comprises genetic, epigenetic, and environmental factors such as dysfunction of the immune system. Epigenetic mechanisms are mainly represented by DNA methylation, histone modifications, and microRNAs (miRNA).
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- - The study aims to evaluate the presence of synaptic damage biomarkers in individuals with Alzheimer's disease (AD) compared to cognitively unimpaired (CU) people through a systematic review and meta-analysis.
- - After reviewing 204 articles, 23 studies were included in the systematic review and 15 in the meta-analysis, revealing significant increases in the cerebrospinal fluid levels of Neurogranin, SNAP-25, and GAP-43 in AD patients compared to CU individuals.
- - The findings suggest that these synaptic biomarkers could help in diagnosing AD, but the current research is relatively limited and shows a lot of variation in results across studies.