Publications by authors named "T Borikun"
Article Synopsis
- Current markers for oral squamous cell carcinoma (OSCC) are often inaccurate, potentially resulting in poor treatment choices; new markers could improve patient treatment and survival rates.
- The study evaluates the potential of miRNA levels in saliva (specifically miR-21, miR-155, and miR-375) as prognostic indicators for the effectiveness of neoadjuvant chemotherapy (NACT) in patients with stage II-IV OSCC.
- Results show that miR-21 and miR-155 levels are higher in OSCC patients compared to healthy individuals, and patients who respond well to NACT have distinct miRNA expression patterns, suggesting these could serve as valuable biomarkers for treatment response.
Background: Breast cancer (BCa) is one of the most common oncological diseases in women in Ukraine and worldwide, which determines the need to search for new diagnostic and prognostic markers. In this aspect, the study of multicellular proteins, in particular osteopontin (OPN) and osteonectin (ON), in BCа tissue is relevant. The aim of the work was to investigate the expression of SPP1 and SPARC at the mRNA and protein levels in BCa tissue and to assess their relationship with the main clinicopathological BCa characteristics and the survival rates of patients.
View Article and Find Full Text PDFBackground: Breast cancer (BC) in young women remains a significant public health concern. While progress has been made in understanding the etiology, diagnosis, and treatment of BC in this population, challenges persist. The identification and utilization of prognostic biomarkers offer valuable tools for tailoring treatment strategies and improving outcomes for BC patients.
View Article and Find Full Text PDFBackground: The tumor microenvironment (TME) plays an important role in the occurrence and progression of prostate cancer (PCa). At the same time, the mechanisms and features of the interaction between tumor cells and individual components of the TME in PCa remain not fully elucidated. The aim was to study the expression levels of tumor-associated miR-7-5p, miR-19a-3p, and miR-23b-3p in the PCa tissue and to analyze their relationship with the features of TME.
View Article and Find Full Text PDFBackground: Prostate cancer (PCa) is common malignancy among men worldwide. To date only few molecular markers are available to predict its course and outcome. SPARC is considered to be promising prognostic marker of PCa due to its involvement in various cancer processes.
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