Publications by authors named "T Bongers"
Article Synopsis
- Lung cancer is a prevalent type of cancer, and despite existing diagnostic methods like X-rays and CT scans, there is a pressing need for faster and non-invasive early detection techniques.
- A novel saliva "dip" test analyzed through advanced spectroscopy and statistical models was developed, utilizing 1944 samples, including both lung-cancer positive and control groups.
- The results showed high sensitivity (100%) and specificity (99.1%), identifying key wavenumbers associated with lung cancer, which indicates a promising approach for differentiating between healthy and cancerous samples using biospectroscopy.
Saliva is a largely unexplored liquid biopsy that can be readily obtained noninvasively. Not dissimilar to blood plasma or serum, it contains a vast array of bioconstituents that may be associated with the absence or presence of a disease condition. Given its ease of access, the use of saliva is potentially ideal in a point-of-care screening or diagnostic test.
View Article and Find Full Text PDFThere is an increasing need for inexpensive and rapid screening tests in point-of-care clinical oncology settings. Herein, we develop a swab "dip" test in saliva obtained from consenting patients participating in a lung-cancer-screening programme being undertaken in North West England. In a pilot study, a total of 211 saliva samples ( = 170 benign, 41 designated cancer-positive) were randomly taken during the course of this prospective lung-cancer-screening programme.
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