Controlled, one-pot synthesis of recyclable poly(1,3-diene)-polyester block copolymers, catalyzed by yttrium β-diketiminate complexes.

The one-pot synthesis of well-defined block copolymers of olefins/1,3-dienes and polar monomers, such as cyclic esters and acrylates has long been the focus of intense research. Cationic alkyl rare earth metal catalysts, activated by organoborates, have shown to be promising for the polymerization of isoprene or styrene and ε-caprolactone. In this study, we synthesize a series of yttrium bis(alkyl) complexes supported by simple β-diketiminate ancillary ligands.

Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline.

Objective: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton pump inhibitors (PPIs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes.

Methods: Five health professionals (1 family physician, 3 pharmacists, and 1 gastroenterologist) and 5 nonvoting members comprised the overall team; members disclosed conflicts of interest. The guideline process included the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach, with a detailed evidence review in in-person, telephone, and online meetings.

Deprescribing versus continuation of chronic proton pump inhibitor use in adults.

Background: Proton pump inhibitors (PPIs) are a class of medications that reduce acid secretion and are used for treating many conditions such as gastroesophageal reflux disease (GERD), dyspepsia, reflux esophagitis, peptic ulcer disease, and hypersecretory conditions (e.g. Zollinger-Ellison syndrome), and as part of the eradication therapy for Helicobacter pylori bacteria.