Publications by authors named "T Boekhout"
ABSTRACTsLactoferrin (LF) is a glycoprotein, a member of the transferrin family, and is present in a variety of secretory fluids, including milk, saliva, tears, and mucosal secretions. Iron binding, immunological regulation, antibacterial action, and intestinal nutrition absorption are only a few of its important biological roles. Although much research has been done on human lactoferrin (hLF), LF derived from different animals is equally essential for physiology and health.
View Article and Find Full Text PDFTyping of feces-derived Candida albicans strains using a novel seven-locus microsatellite panel reveals associations with yeast phenotype in individuals with inflammatory bowel disease.
Pathog Dis
January 2025
Inflammatory diseases of the human gastrointestinal tract are affected by the microbes that reside in the mucosal surfaces. Patients with inflammatory bowel diseases (IBD) have altered bacterial and fungal intestinal compositions, including higher levels of fecal Candida yeasts. Ongoing research indicates that genetic and phenotypic diversity of Candida albicans may be linked with disease severity.
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- The study focuses on developing a MALDI-TOF MS database for the accurate identification of various species from a specific microorganism complex, overcoming previous misidentifications.
- It involved analyzing 71 isolates, creating a new database with 37 strains using a formic acid extraction method, and validating it with an additional 34 strains.
- The database successfully achieved 100% identification accuracy, showing that MALDI-TOF MS is a reliable tool for diagnosing infectious agents in clinical settings.
causes life-threatening invasive infections that are hard to diagnose and treat, with drug resistance leading to treatment failure. The goal of this study was to develop VHH (single variable domain on a heavy chain) nanobodies to detect drug-resistant infections. Llamas were immunized with a mixture of heat killed and fixed cells of different morphologies.
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- A lipophilic yeast found in breast tumors may contribute to the faster progression of breast cancer (BRAC) in patients, though the specific mechanisms behind this relationship are not yet clear.
- Research demonstrated that this yeast can colonize mammary tissue in animal models, leading to a decrease in overall survival and an increase in tumor formation.
- Key findings indicate the involvement of IL-17A and tumor-associated macrophages, with Sphingosine kinase 1 (Sphk1) playing a significant role in tumor growth related to the yeast's colonization.