Publications by authors named "T Bocker-Edmonston"
Mixed pancreatic ductal adenocarcinoma and well-differentiated neuroendocrine tumor: A case report.
World J Gastrointest Oncol
December 2024
Background: Pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies affecting the pancreas. The World Health Organization defines MiNENs as neoplasms composed of morphologically recognizable neuroendocrine and non-neuroendocrine components, each constituting 30% or more of the tumor volume. Adenocarcinoma-neuroendocrine carcinoma is the most frequent MiNEN combination.
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- Testing for mismatch repair deficiency (dMMR) and high-grade microsatellite instability (MSI-H) is crucial for diagnosing colorectal cancer and predicting response to immune therapies.
- Originally linked to Lynch syndrome, MSI is now important in the treatment of various cancers beyond CRC, including endometrial and gastric cancers.
- The review highlights the importance of quality assurance measures in testing, the challenges of assessing results, and the potential of Next Generation Sequencing in improving diagnostic accuracy.
Article Synopsis
- Testing for mismatch repair deficiency (dMMR) and high-grade microsatellite instability (MSI-H) is now standard in diagnosing colorectal cancer and influences therapy response to immune checkpoint inhibitors (ICI).
- The review discusses the shift in focus from hereditary cancer risk (like Lynch syndrome) to the role of these tests in guiding treatment options for a variety of cancers, not just colorectal.
- A practical flowchart is included for clinicians, highlighting challenges in testing methods and the importance of quality assurance and training in improving diagnostic accuracy.
Introduction: Monoclonal protein bands are present mainly in blood and secondary in urine representing specific antibody produced in excess by abnormal lymphocytes or plasma cells.We describe a case of a patient with acute encephalitis associated with an unexpected finding of a monoclonal protein band present in blood, urine and in cerebrospinal fluid (CSF).
Case Presentation: This 50-year-old woman with no significant past medical history, with the exception of unintentional weight loss exceeding 5 kg over the last 3 months, presented to the emergency department with seizures and altered mental status, after 3 days of vomiting and headaches.