Publications by authors named "T Blanco"
Background: After almost 70 years of using indoor residual spraying (IRS) as the primary intervention for malaria vector control, the Republic of Panama wanted to evaluate the operational feasibility and acceptability of distributing long-lasting insecticidal hammock nets (LLIHNs) and long-lasting insecticidal nets (LLINs) in the country.
Methods: A pilot study conducted in 2019 distributed LLINs and LLIHNs to cover all sleeping spaces in 15 high burden localities of the indigenous Comarca of Guna Yala and measured retention, coverage, use and physical deterioration, washing and drying practices, as well as people's satisfaction with product characteristics post-distribution.
Results: Overall, 89.
There is an unmet need for effectively treating dry eye disease (DED), a T cell-mediated chronic, inflammatory ocular surface disorder. Given the potential of nonneuronal adrenergic system in modulating T cell response, we herein investigated the therapeutic efficacy and the underlying mechanisms of a specific alpha 2 adrenergic receptor agonist (AGN-762, selective for α2B/2C receptor subtypes) in a mouse model of DED. Experimental DED was treated with the AGN-762 by oral gavage, either at disease induction or after disease establishment, and showed sustained amelioration, along with reduced expression of DED-pathogenic cytokines in ocular surface tissues, decreased corneal MHC-IICD11b cells and lymphoid Th17 cells, and higher function of regulatory T cells (Treg).
View Article and Find Full Text PDF: In this study, we establish a protocol for evaluating the outcomes of endothelial keratoplasty, including graft survival, rejection, or failure. Additionally, we also evaluate the alloimmune response in graft recipients. : We performed EK using C57BL/6 (allogeneic) and BALB/c (syngeneic) as donors and BALB/c mice as recipients.
View Article and Find Full Text PDFArticle Synopsis
- T helper 1 (Th1)-mediated immune rejection is the main reason for graft failure after transplantation, influenced by interactions between different types of dendritic cells, particularly CD11b+ DC2 and CD103+ DC1.
- In non-inflamed corneal beds, migratory CD103+ DC1 cells maintain a tolerogenic function that helps suppress harmful immune responses and promote graft survival through mechanisms like IL-10 and the PD-L1/PD-1 pathway.
- In contrast, in inflamed corneal beds, Th1 cells switch CD103+ DC1 cells to an immunostimulatory state, leading to graft failure; however, transferring tolerogenic CD103+ DC1s can inhibit this negative
Article Synopsis
- This text examines how mesenchymal stem/stromal cells (MSCs) interact with the immune system of the cornea and their potential to treat eye disorders.
- It discusses the immune privilege of the cornea, highlighting key immunomodulatory substances and the regenerative properties of MSCs.
- The article focuses on MSCs' effectiveness in treating various corneal diseases, showing promise in promoting healing and reducing inflammation based on both preclinical and clinical studies.