Publications by authors named "T Billard-Pomares"
Article Synopsis
- Pulmonary tuberculosis (PT) is highly contagious, which necessitates immediate isolation of suspected patients upon admission and the use of specific precautions to prevent airborne transmission.
- A study in a high-prevalence hospital found that over a third of PT patients (34%) were not properly isolated within the first 24 hours of admission, with an average delay of 4.3 days for implementing airborne precautions.
- Factors influencing isolation included previous consultations with general practitioners being beneficial, while admissions through emergency departments led to a higher risk of non-isolation, and European patients were less frequently isolated compared to others.
The process of whole genome sequencing of the Mycobacterium tuberculosis complex is dependent on complete the inactivation of the strain and subsequent DNA extraction. The objective of this study was to optimise the two steps. Firstly, the efficacy of Triton X-100 as a solvent for the inactivation step was evaluated.
View Article and Find Full Text PDFMycobacterium tuberculosis complex (MTBC) has a population structure consisting of 9 human and animal lineages. The genomic diversity within these lineages is a pathogenesis factor that affects virulence, transmissibility, host response, and antibiotic resistance. Hence it is important to develop improved information systems for tracking and understanding the spreading and evolution of genomes.
View Article and Find Full Text PDFWhole-genome sequencing of Mycobacterium tuberculosis complex (MTBC) strains is a rapidly growing tool to obtain results regarding the resistance and phylogeny of the strains. We evaluated the performances of two bioinformatics tools for the analysis of whole-genome sequences of MTBC strains. Two hundred and twenty-seven MTBC strains were isolated and whole-genome sequenced at the laboratory of Avicenne Hospital between 2015 and 2021.
View Article and Find Full Text PDF