Publications by authors named "T Behlendorf"
Purpose: The CLL12 trial reassesses the watch-and-wait consensus for early-stage chronic lymphocytic leukemia (CLL) in the context of targeted therapies.
Methods: The German CLL Study Group conducted a randomized, double-blind, placebo-controlled phase III trial with 363 patients with asymptomatic, treatment-naïve Binet stage A CLL at increased risk of progression to receive ibrutinib (n = 182) at a daily dose of 420 mg or placebo (n = 181). Additionally, 152 low-risk patients were allocated to the watch-and-wait group.
Article Synopsis
- The study investigates the immune responses of patients with blood cancers receiving checkpoint-inhibitors after vaccination against SARS-CoV-2, comparing their outcomes with those of healthy controls.
- Results showed that while initial seroconversion (antibody response) was lower in patients (68%) compared to controls (98%), there was a significant improvement by day 120 across all patient groups, particularly for those on checkpoint-inhibitors.
- The research highlights that despite some patients showing T-cell responses, there was no clear link between antibody levels and T-cell responses, suggesting that evaluating both immune responses is important for understanding patient immunity and guiding public health vaccination strategies.
Background: Prognosis of patients with multiple myeloma (MM) who have relapsed on or become refractory to immunomodulators and bortezomib is poor, and treatment options are limited. While pomalidomide plus low-dose dexamethasone (POM/DEX) has demonstrated efficacy in clinical trials, real-world evidence is scarce.
Patients And Methods: POSEIDON was a prospective non-interventional study designed to evaluate effectiveness, safety and quality of life (QoL) of POM/DEX in patients with relapsed or refractory MM (R/RMM) pretreated with at least two prior therapy lines including both lenalidomide and bortezomib in real world in Germany.
Diagnostic work-up for the detection of malnutrition in hospitalized cancer patients.
J Community Support Oncol
April 2016
Background: Malnutrition is a common complication in patients suffering from cancer. It is associated with a poor prognosis, reduced quality of life, increased chemotherapy-induced toxicity, and a decreased response to therapy.
Objective: To evaluate and compare the use of various diagnostic tests for the detection of malnutrition in patients hospitalized for cancer treatment.
Objectives: Although rare, neoplastic meningitis (NM) has been increasingly observed in patients with cancer due to the prolonged course of the disease. Intrathecal chemotherapy with methotrexate or cytarabine with repeating injection schedules of 2-3 times per week is currently the mainstay of treatment. An efficacious and comfortable treatment alternative might be represented by liposomal cytarabine.
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