Support for Research Biobanks Among Medical Students in the Republic of Kazakhstan.

Over the past few years, several biobanks have been organized in the Republic of Kazakhstan (RoK). As research biobanks are becoming an increasingly important tool for precision medicine, they require competent biobankers who will help disseminate the idea of biobanking throughout the society and support donation for research purposes. This study aimed to assess the support for research biobanks among medical students (MSs) in Kazakhstan.

The cortisol levels in the follicular and luteal phases of the healthy menstruating women: a meta-analysis.

Objective: The conflicting results of the previous studies regarding the serum cortisol through the menstrual cycle warranted further research. We aimed to detect the cortisol levels in the follicular and luteal phases of healthy menstruating women.

Materials And Methods: A literature search was conducted by two independent authors according to PRISMA criteria over PubMed, Web of Science and Psych-Info to retrieve the articles published in English from 1990 until 2020 and containing the keywords, Cortisol, Menstrual, Follicular, or Luteal.

[MOLECULAR GENETIC ASPECTS OF THE DEVELOPMENT OF THE MUCOPOLYSACCHARIDOSES (REVIEW)].

The review highlights the current knowledge about the potential role of glycosaminoglycans in the induction of inflammation and development of damage of the functional systems of the organs by mucopolysaccharides (MPS). Undegraded glycosaminoglycans are stimulants of secondary events in the form of complex pathogenetic cascades: accumulation of secondary substrates unrelated to the defective enzyme, abnormal composition of the membranes, disorders of intracellular vesicular transport, impairment of autophagy, change of intracellular signaling (aberrant activation of signaling pathways), abnormalities of calcium homeostasis, oxidative stress. Understanding of the cellular processes underlying the pathophysiology of MPS helps to address the limitations of the existing therapies and to identify new therapeutic targets, which potentially form additional and effective ways of the therapy of the patients with MPS.