Publications by authors named "T Barth"
Background: Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome characterized by a high familial incidence of various malignancies. It results from pathogenic/likely pathogenic heterozygous constitutional variants of the TP53 gene. Due to impaired DNA damage repair, conventional cytotoxic therapies or radiotherapy should be avoided whenever feasible to mitigate the high incidence of treatment-related secondary malignancies in these patients.
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- Human adenovirus type 5 (HAdV-5)-based oncolytic viruses have potential for cancer therapy, but face challenges like poor targeting and liver toxicity.
- Researchers created a modified HAdV-5 vector (HAdV-5-HexPos3_ΔCAR) that improves cancer cell targeting and reduces off-target effects, especially in liver tissues.
- The modified vector showed a significant increase in tumor presence while minimizing adverse effects, suggesting it could enhance the efficacy and safety of adenoviral cancer treatments.
Background: Most challenging treatment needs are in recurrent or persisting head and neck squamous cell carcinoma (HNSCC) patients after (((chemo-)radiotherapy) (C)RT).
Materials And Methods: This 10-year retrospective study included 100 patients, who initially received (C)RT followed by neck dissection (ND). The results of computed tomography (CT) and sonography were evaluated for residual/recurrent cervical lymph nodes and compared to the histopathology.
Background: Complex fractures of the trochanteric region, as well as fractures located in the directly subtrochanteric region, are controversially discussed around the world regarding the nail type to be used. A long nail is recommended by manufacturers but requires longer surgical and fluoroscopy times. A possible solution could be a nail with an appropriate length which can be locked in a minimally invasive manner by the main aiming device.
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