Publications by authors named "T Baranyai"
Article Synopsis
- The study investigates cardioprotective microRNAs (protectomiRs) in a pig model of acute myocardial infarction (AMI) to find potential therapeutic options for heart protection.
- Researchers analyzed changes in miRNA expression in cardiac tissues and validated candidates in lab models using rat and human heart cells.
- The findings highlight miR-450a as a significant protectomiR, linked to protection during ischemic conditions and having common pathways and targets across species, making it a strong candidate for future heart therapies.
Article Synopsis
- Cardiac hypertrophy, triggered by sympathetic nervous system activation, can lead to heart failure, and the transcription factor YB-1 may play a key role in managing this process.
- In human heart biopsies from patients with ischemic cardiomyopathy, YB-1 expression is found to be downregulated, which correlates with the development of heart failure.
- Research using siRNA techniques on cardiac cells indicates that reducing YB-1 leads to increased hypertrophic growth, while overexpressing YB-1 can inhibit hypertrophic responses under certain stimuli, suggesting that maintaining YB-1 levels is crucial for heart protection.
The role of coronary computed tomography angiography (CCTA) derived fractional flow reserve (CT-FFR) in the assessment of non-culprit lesions (NCL) in patients with acute coronary syndrome (ACS) is debated. In this prospective clinical study, a total of 68 ACS patients with 89 moderate (30−70% diameter stenosis) NCLs were enrolled to evaluate the diagnostic accuracy of on-site CT-FFR compared to invasive fractional flow reserve (FFRi) and dobutamine stress echocardiography (DSE) as reference standards. CT-FFR and FFRi values ≤0.
View Article and Find Full Text PDFLittle is known about the role of the neuropeptide somatostatin (SST) in myocardial ischemia/reperfusion injury and cardioprotection. Here, we investigated the direct cardiocytoprotective effect of SST on ischemia/reperfusion injury in cardiomyocyte cultures, as well as the expression of SST and its receptors in pig and human heart tissues. SST induced a bell-shaped, concentration-dependent cardiocytoprotection in both adult rat primary cardiomyocytes and H9C2 cells subjected to simulated ischemia/reperfusion injury.
View Article and Find Full Text PDFFractional flow reserve (FFR) measurement was compared to dobutamine stress echocardiography (DSE) instable angina (SA) with stable coronary lesion (s) (SCL (s) ) in a few trials; however, similar comparisons in patients with acute coronary syndrome (ACS) with non-culprit lesion (s) (NCL (s) ) are lacking. Our objectives were to prospectively evaluate the diagnostic performance of FFR with two different cutoff values (< 0.80 and < 0.
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