Introduction: To assess the susceptibility of epidemic influenza viruses to the four most used neuraminidase inhibitors (NAIs) during the 2023-24 influenza season in Japan, we measured the 50 % inhibitory concentration (IC) of oseltamivir, peramivir, zanamivir, and laninamivir in virus isolates from the sample of 100 patients.
Methods: Viral isolation was done using specimens obtained before and after treatment, with the type/subtype determined by RT-PCR using type- and subtype-specific primers. IC values were determined by a neuraminidase inhibition assay using a fluorescent substrate.
Rev Sci Instrum
December 2024
Soft x-ray (SX) tomography is a useful diagnostic in fusion research, and a multi-channel SX diagnostic will be installed in JT-60SA, the largest elongated tokamak in the world. However, in the SX diagnostic of JT-60SA, plasmas will be only viewed from the low field side and the upper side of plasmas; the sight lines are limited, which would be common in future devices as well as JT-60SA. This kind of limited sight lines is not preferred for SX tomography to investigate the spatial structure of magnetohydrodynamics (MHD) modes because inadequate information of plasmas makes artifacts in the reconstructed SX profiles.
View Article and Find Full Text PDFBackground: Clinical data on patients infected with influenza B Victoria (BV) after the approval of baloxavir is lacking.
Methods: This observational study of the Japanese 2023-2024 influenza season analyzed data from 25 outpatients with A(H1N1)pdm09, 36 with A(H3N2), and 65 with BV. Viral samples were collected before and after administering an antiviral (70 patients received baloxavir and 56 received a neuraminidase inhibitor), on days 1, 5, and 10.
Interdiscip Cardiovasc Thorac Surg
October 2024