Publications by authors named "T Bailly"
The C-X-C chemokine receptor 4 (CXCR4) is highly upregulated in most cancers, making it an ideal target for delivering radiation therapy to tumors. We previously demonstrated the feasibility of targeting CXCR4 in vivo using a radiolabeled derivative of EPI-X4, an endogenous CXCR4 antagonist, named DOTA-K-JM#173. However, this derivative showed undesirable accumulation in the kidneys, which would limit its clinical use.
View Article and Find Full Text PDFProtein-carbohydrate interactions govern a wide variety of biological processes and play an essential role in the development of different diseases. Here, we present DIONYSUS, the first database of protein-carbohydrate interfaces annotated according to structural, chemical and functional properties of both proteins and carbohydrates. We provide exhaustive information on the nature of interactions, binding site composition, biological function and specific additional information retrieved from existing databases.
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- Being part of a group helps cooperation among members but also creates competition for resources, especially for pregnant females whose offspring benefit from resource availability relative to group size.
- In the fruit fly Drosophila melanogaster, females attract others to lay eggs together, and the study shows that females lay eggs faster in larger groups compared to when they are isolated, which aids in reducing competition and enhancing offspring survival.
- The study also finds that group-laying females shift their egg-laying behavior to daytime and suggests that visual cues and hormonal changes, rather than mere solitary versus social classifications, greatly influence reproductive strategies in these flies.
Bivalent ligands, i.e., molecules having two ligands covalently connected by a linker, have been gathering attention since the first description of their pharmacological potential in the early 80s.
View Article and Find Full Text PDFThe influence of oncogenic phenomena on the ecology and evolution of animal species is becoming an important research topic. Similar to host-pathogen interactions, cancer negatively affects host fitness, which should lead to the selection of host control mechanisms, including behavioral traits that best minimize the proliferation of malignant cells. Social behavior is suggested to influence tumor progression.
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