Polarity reversal, or "umpolung", is a widely acknowledged strategy to allow organic functional groups amenable to react in alternative ways to the usual preference set by their electronic features. In this article, we demonstrate that cyclohexyne umpolung, realized through complexation to zirconocene, makes the small strained cycloalkyne amenable to C-F bond functionalisation. Such strong bond activation chemistry is unprecedented in "free" aryne and strained alkyne chemistry.
View Article and Find Full Text PDFObjective: Beginning academic year 2021, a curricular redesign was implemented, including a transition from resident-led to faculty-led lectures during didactics. We aimed to survey residents and faculty on their perceptions of engagement and clinical preparedness following this change.
Design: This was a retrospective cohort study investigating the effects of curricular change on resident and faculty perceptions of the program.
Objective: The objective of this study was to understand the resident perspective on what makes an excellent surgical educator and to identify gaps in a single-institution-developed "Residents as Teachers" curriculum (RaTC) following the completion of the RaTC by residents at the institution.
Design: A longitudinal 8-hour RaTC was developed and administered in 1-hour sessions over 2 years. Content included interactive clinical and technical skills teaching, feedback, evaluation and assessment, and interpersonal skills.
We investigated if the efficacy of a Chlamydia abortus (Cab) subunit vaccine is influenced by route of administration. Thus, female CBA/J mice were immunized either by mucosal or systemic routes with Vibrio cholerae ghost (VCG)-based vaccine expressing T and B cell epitopes of Cab polymorphic membrane protein (Pmp) 18D, termed rVCG-Pmp18.3.
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