[Results of using Solanum tuberosum sprouts extract for the treatment of ophthalmoherpes].

The efficacy, tolerability and safety of the extract of Solanum tuberosum sprouts (Panavir eyedrops) have been studied on the model of ophthalmic disorder in rabbits caused by herpes simplex virus (HSV) type 1. It is established that Panavir applied via 6 instillations per day for a period of days has potent therapeutic efficacy and prevents the development of gross corneal opacity in rabbits. Instillation of Panavir eyedrops does not cause irritation, toxic and allergic effects and are well tolerated by rabbits.

[A toxicological study of a phytopreparation made from an extract of alfalfa (Medicago sativa)].

A phytopreparation from lucerne (Medicago sativa) was studied with respect to the acute and chronic toxicity and the action upon the cellular genetic mechanism. It was found that the preparation belongs to the group of practically nontoxic properties.

[The development of a nutrient medium for Bifidobacterium bifidum biomass accumulation in continuous cultivation processes in a bioreactor].

A new nutrient medium for the cultivation of bifidobacteria, containing dry nutrient bases of the Bactofoc series, has been developed. The nutrient medium composition has been adjusted by modern methods with the use of a model Bioscreen apparatus permitting the study of growth kinetics in 200 cultivation processes simultaneously. The new nutrient medium has been used in the development of the continuous flow cultivation of bifidobacteria in a bioreactor under anaerobic conditions.

[Prospects for using the SOS-Chromotest for predicting carcinogenic activity of chemical compounds].

When studying the carcinogenic activity of a compound, one of the basic problems is to determine the predictability of the methods used for testing; in our opinion, the most promising method is the SOS chromotest. To evaluate the test, we sampled 25 substances with a known carcinogenic activity, which had not been tested with the SOS chromotest before. Properties of the SOS chromotest were analyzed on the basis of a database containing 154 substances at present, which are characterized with regard to the presence or absence of a carcinogenic effect in rodents.