Publications by authors named "T B Safonova"
[The role of meibum proteins in the pathogenesis of meibomian gland dysfunction].
Vestn Oftalmol
March 2025
Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality.
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- - Dry eye disease (DED) is primarily caused by inflammation on the surface of the eye, and treating it effectively starts with early anti-inflammatory medications like cyclosporine A (CsA).
- - There is a lack of comprehensive recommendations for how to use topical CsA in treating DED in real-world clinical settings.
- - The article provides expert consensus on practical guidelines for DED management, covering when to start CsA, how long to use it, comparing CsA products approved in Russia, and the importance of educating patients.
The lacrimal gland (LG) is a tubuloacinar exocrine gland composed of acinar, ductal, and myoepithelial cells. Three-dimensional distribution of acinar lobules, ducts, and myoepithelial cells is necessary for the effective functioning of the organ. LG is the main organ of immune surveillance of the ocular surface system.
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- Chronic mixed blepharitis is a common eye condition, making up 51.7% of ophthalmic diseases, and LDF (laser Doppler flowmetry) can help diagnose its early inflammatory signs to prevent complications like dry eye disease.
- A study involving 23 patients with chronic mixed blepharitis and 18 healthy volunteers evaluated the effectiveness of LDF in detecting microcirculatory changes in the eyelid skin.
- Results indicated that LDF has high sensitivity and specificity in identifying eyelid damage related to chronic mixed blepharitis, making it a useful diagnostic tool alongside other clinical methods.
The role of phosphate-coordinating arginine residues in the thermal stability of uridine phosphorylase from Shewanella oneidensis MR-1 was investigated by mutation analysis. Uridine phosphorylase mutant genes were constructed by site-directed mutagenesis. The enzyme mutants were prepared and isolated, and their kinetic parameters were determined.
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