3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes wound healing and angiogenesis.

Biomaterial composition and surface charge play a critical role in macrophage polarization, providing a molecular cue for immunomodulation and tissue regeneration. In this study, we developed bifunctional hydrogel inks for accelerating M2 macrophage polarization and exosome (Exo) cultivation for wound healing applications. For this, we first fabricated polyamine-modified three-dimensional (3D) printable hydrogels consisting of alginate/gelatin/polydopamine nanospheres (AG/NSPs) to boost M2-exosome (M2-Exo) secretion.

Electroconductive Nanocellulose, a Versatile Hydrogel Platform: From Preparation to Biomedical Engineering Applications.

Nanocelluloses have garnered significant attention recently in the attempt to create sustainable, improved functional materials. Nanocellulose possesses wide varieties, including rod-shaped crystalline cellulose nanocrystals and elongated cellulose nanofibers, also known as microfibrillated cellulose. In recent times, nanocellulose has sparked research into a wide range of biomedical applications, which vary from developing 3D printed hydrogel to preparing structures with tunable characteristics.

Tailoring osteoimmunity and hemostasis using 3D-Printed nano-photocatalytic bactericidal scaffold for augmented bone regeneration.

Bone hemorrhage, infection, and large bone defects following surgical treatment of traumatic bone injury have raised potential concerns, underscoring the urgent need to develop multifunctional therapeutic platforms that can effectively address traumatic bone regeneration. Advancements in three-dimensional (3D) printing technology have propelled the development of several engineering disciplines, such as tissue engineering. Nevertheless, 3D-printed frameworks with conventional materials often lack multifunctional capabilities to promote specific activities for diverse regeneration purposes.

Comparative Evaluation of Microleakage in Class II Composite Restorations Using Three Bulk-fill Composites with or without Resin-modified Glass Ionomer Cement Liner: A Stereomicroscopic Study.

Aim: To compare the microleakage of three bulk-fill composite resins with or without resin-modified glass ionomer cement (RMGIC) liner.

Materials And Methods: A total of 30 maxillary human 1st premolar teeth were selected. Two box preparations were made on the mesial and distal sides.