Publications by authors named "T B Morais"
Innovative strategies for targeted anticancer therapies have gained significant momentum, with metal complexes emerging as tunable catalysts for more effective and safer treatments. Rational design and engineering of metal complexes enable the development of tailored molecular structures optimized for precision oncology. The strategic incorporation of metal complex catalysts within combinatorial therapies amplifies their anticancer properties.
View Article and Find Full Text PDFArticle Synopsis
- Adenosine acts as a natural anticonvulsant through adenosine receptors (AR), but developing drugs that target these receptors has been challenging due to potential cardiac side effects.
- The study examined the effects of a selective AR agonist called MRS5474 on excitatory and inhibitory signals in the hippocampus, using both rodent and human tissue samples.
- Results showed that MRS5474 does not affect normal excitatory signals but enhances GABAergic currents in tissue from patients with epilepsy, suggesting its potential as a targeted antiseizure medication through activation of AR in epileptic conditions.
Article Synopsis
- The Iguaçu River basin has a unique fish population but is threatened by chemical pollution, especially from the Jordão River, which drains contaminated agricultural and industrial areas.
- A study found that while most contaminants were within Brazilian legal limits, cadmium, aluminum, and lead were found at harmful levels in certain locations, affecting fish embryos and larvae.
- The research demonstrates that even low-level pollutants can increase mortality and deformity rates in aquatic organisms, highlighting the need for conservation efforts to protect local wildlife and maintain ecological health.
In the search for innovative, selective, effective, and safer treatment strategies, hybrid drugs have gained worldwide momentum [...
View Article and Find Full Text PDF