Publications by authors named "T B Malankhanova"
Article Synopsis
- The study explores the aggregation process of α-synuclein, a protein linked to Parkinson's Disease and Multiple System Atrophy, and its implications for research.
- Researchers determined the first atomic structure of mouse α-synuclein fibrils, revealing similarities to fibrils found in human conditions, but with important differences in their properties.
- The findings indicate that mouse α-synuclein fibrils have altered behaviors, suggesting a need to reevaluate their use in developing diagnostic tools and treatments for related diseases.
Background: LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson's disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of immunological responses. The identification of factors that regulate LRRK2-mediated Rab10 phosphorylation in iPD, and whether phosphorylated-Rab10 levels change in different disease states, or with disease progression, may provide insights into the role of Rab10 phosphorylation in iPD and help guide therapeutic strategies targeting this pathway.
View Article and Find Full Text PDFBackground: LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson's disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of immunological responses. The identification of factors that regulate LRRK2-mediated Rab10 phosphorylation in iPD, and whether phosphorylated-Rab10 levels change in different disease states, or with disease progression, may provide insights into the role of Rab10 phosphorylation in iPD and help guide therapeutic strategies targeting this pathway.
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- * Researchers analyzed dopaminergic neurons derived from induced pluripotent stem cells (iPSCs) of individuals with the mutation (GBA-PD), asymptomatic carriers (GBA-carrier), and healthy controls to assess the activity of lysosomal enzymes.
- * Findings revealed that GBA-PD neurons exhibit lower glucocerebrosidase (GCase) activity and altered activity in other lysosomal enzymes compared to GBA-carrier and control neurons, indicating the need for further research into the genetic and environmental factors influencing PD development.
Huntington's disease (HD) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (HTT) protein. In HD, dysregulation of multiple cellular processes occurs, resulting in the death of medium spiny neurons of striatum. A line of induced pluripotent stem cells (iPSCs) ICGi033-A was obtained from peripheral blood mononuclear cells of a patient carrying 77 CAG repeats in the HTT gene.
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