Publications by authors named "T B M Hakvoort"
Article Synopsis
- The study investigates the potential of using DNA methylation patterns in peripheral blood to predict response to adalimumab (ADA) treatment in rheumatoid arthritis (RA) patients, as current biomarkers are lacking.
- Researchers analyzed DNA methylation in 92 RA patients before starting ADA and classified them as responders or non-responders after 6 months based on disease activity scores.
- A machine learning model successfully distinguished responders from non-responders with an accuracy of 76% using a set of 27 specific DNA markers associated with immune function in RA.
Innervation of the intestinal mucosa by the sympathetic nervous system is well described but the effects of adrenergic receptor stimulation on the intestinal epithelium remain equivocal. We therefore investigated the effect of sympathetic neuronal activation on intestinal cells in mouse models and organoid cultures, to identify the molecular routes involved. Using publicly available single-cell RNA sequencing datasets we show that the α isoform is the most abundant adrenergic receptor in small intestinal epithelial cells.
View Article and Find Full Text PDFBackground: Understanding the early processes underlying intestinal anastomotic healing is crucial to comprehend the pathophysiology of anastomotic leakage. The aim of this study was to assess normal intestinal anastomotic healing and disturbed healing in rats to investigate morphological, cellular and intrinsic molecular changes in the anastomotic tissue.
Method: Anastomoses were created in two groups of Wistar rats, using four sutures or 12 sutures to mimic anastomotic leakage and anastomotic healing respectively.
Hepatocellular carcinoma (HCC) is a primary liver cancer commonly found in adults. Previously, we showed the anticancer effects of Thai herbal plant extract, Pierre (DM), in HCC-bearing rats. In the present study, we further examined the proposed mechanism of DM, including apoptosis and antioxidant activity.
View Article and Find Full Text PDFBackground: SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn's disease (CD), suggesting a role in inflammation.
Results: We report the development of the first small molecule SP140 inhibitor (GSK761) and utilize this to elucidate SP140 function in macrophages.