Publications by authors named "T B H Geijtenbeek"
Article Synopsis
- HIV-1 modifies tetraspanins like CD9 to enhance its entry and replication within host cells, highlighting CD9's important role during infection.
- Researchers created specialized nanobodies from llamas that target CD9, discovering several that bind effectively and have potential in combatting HIV-1.
- These nanobodies didn't stop the initial virus lifecycle but were successful in preventing fusion of infected cells and reducing HIV-1 replication in immune cells, suggesting new treatment options alongside current antiretrovirals.
Article Synopsis
- Antiretroviral treatment can't get rid of all the HIV in the body, and stopping treatment often doesn't help the immune system fight HIV.
- Researchers looked at T cells, a type of immune cell, in people who don't get worse from HIV (long-term non-progressors) and found that their T cells worked better due to certain signals and activities.
- The study suggests that problems with energy production in immune cells could lead to them not working properly against HIV, and improving this could help find better treatments to boost people's immune responses.
Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells.
J Infect Dis
July 2024
Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells.
View Article and Find Full Text PDFMusculoskeletal simulations can provide insights into the underlying mechanisms that govern animal locomotion. In this study, we describe the development of a new musculoskeletal model of the horse, and to our knowledge present the first fully muscle-driven, predictive simulations of equine locomotion. Our goal was to simulate a model that captures only the gross musculoskeletal structure of a horse, without specialized morphological features.
View Article and Find Full Text PDFArticle Synopsis
- - ILC2s are important for type 2 immunity and play a role in chronic inflammatory conditions like asthma.
- - Research shows that resting ILC2s in humans retain a marker (CD45RO) associated with activated inflammatory ILC2s, while also decreasing another typical marker (CD127) in specific tissues.
- - When isolated and stimulated, these CD127-CD45RO+ ILC2s demonstrate enhanced growth and cytokine production, suggesting that human ILC2s can develop an innate immune memory, prompting a reevaluation of how these cells are identified.